Main |
Browse Volumes |
Forthcoming Volumes |
Annals PrePrints |
Annals Extra |
E-mail Alerts |
Subscriptions & Orders |
New Proposals |
Author Guidelines |
About Annals |
Help |
 |
|
|
|
|
|
Anatomical Substrates for Glutamate-Dopamine Interactions
Evidence for Specificity of Connections and Extrasynaptic Actions
SUSAN R. SESACKa,
DAVID B. CARRb,
NATALIA OMELCHENKOa AND
ALINE PINTOc
aDepartments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
bDepartment of Physiology, Northwestern University, Chicago, Illinois 60611, USA
cCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
Address for correspondence: Susan R. Sesack, Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260. Voice: 412-624-5158; fax: 412-624-9878.
sesack{at}bns.pitt.edu
Ann. N.Y. Acad. Sci. 1003: 36-52 (2003).
For normal regulation of motor, affective, and cognitive functions, dopamine provides an essential modulation of glutamate transmission within multiple brain regions. This paper will review three principal anatomical substrates for such interactions. First, dopamine modulates the activity of glutamate neurons within the cerebral cortex. Evidence will be reviewed for dopamine regulation of pyramidal neurons in the prefrontal cortex via synaptic and extrasynaptic mechanisms and through indirect effects mediated by GABA cells. Second, glutamate neurons innervate dopamine cells within the ventral tegmental area. Evidence will be described for selective glutamate input from the prefrontal cortex or the brain stem tegmentum to different populations of dopamine cells. The third level of interaction occurs within target regions via convergent synaptic or extrasynaptic regulation of common neurons. Such convergence will be reviewed for the basal ganglia, prefrontal cortex, and amygdala. Together, these substrates for glutamate-dopamine interactions provide several mechanisms for normal regulation of brain function. Sites of modulatory interaction between dopamine and glutamate also suggest circuit alterations that might contribute to the pathophysiology of mental health disorders and provide potential sites for therapeutic intervention in these conditions.
Key Words: amygdala • dopamine • GABA • glutamate • laterodorsal tegmentum • pedunculopontine tegmentum • prefrontal cortex • nucleus accumbens • striatum • ventral tegmental area
This article has been cited by other articles:
|
|
|
|
 
X. Sun, M. Milovanovic, Y. Zhao, and M. E. Wolf
Acute and Chronic Dopamine Receptor Stimulation Modulates AMPA Receptor Trafficking in Nucleus Accumbens Neurons Cocultured with Prefrontal Cortex Neurons
J. Neurosci.,
April 16, 2008;
28(16):
4216 - 4230.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Flatscher-Bader, N. Zuvela, N. Landis, and P.A. Wilce
Smoking and alcoholism target genes associated with plasticity and glutamate transmission in the human ventral tegmental area
Hum. Mol. Genet.,
January 1, 2008;
17(1):
38 - 51.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Garraux, P. Peigneux, R. E. Carson, and M. Hallett
Task-Related Interaction between Basal Ganglia and Cortical Dopamine Release
J. Neurosci.,
December 26, 2007;
27(52):
14434 - 14441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Morra
The Neural Substrate of Disappointment Revealed?
J. Neurosci.,
October 3, 2007;
27(40):
10647 - 10648.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. Tan, J. H. Callicott, and D. R. Weinberger
Dysfunctional and Compensatory Prefrontal Cortical Systems, Genes and the Pathogenesis of Schizophrenia
Cereb Cortex,
September 1, 2007;
17(suppl_1):
i171 - i181.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Tomei, A. Capozzella, M. Ciarrocca, P. Fiore, M. Valeria Rosati, M. Fiaschetti, T. Casale, V. Anzelmo, F. Tomei, and C. Monti
Plasma dopamine in workers exposed to urban stressor.
Toxicology and Industrial Health,
August 1, 2007;
23(7):
421 - 427.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Zhang, A. Vinuela, M. H. Neely, P. J. Hallett, S. G. N. Grant, G. M. Miller, O. Isacson, M. G. Caron, and W.-D. Yao
Inhibition of the Dopamine D1 Receptor Signaling by PSD-95
J. Biol. Chem.,
May 25, 2007;
282(21):
15778 - 15789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gao, C.-L. Liu, S. Yang, G.-Z. Jin, B. S. Bunney, and W.-X. Shi
Functional Coupling between the Prefrontal Cortex and Dopamine Neurons in the Ventral Tegmental Area
J. Neurosci.,
May 16, 2007;
27(20):
5414 - 5421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Yacubian, T. Sommer, K. Schroeder, J. Glascher, R. Kalisch, B. Leuenberger, D. F. Braus, and C. Buchel
Gene gene interaction associated with neural reward sensitivity
PNAS,
May 8, 2007;
104(19):
8125 - 8130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. W. BALLEINE and S. B. OSTLUND
Still at the Choice-Point: Action Selection and Initiation in Instrumental Conditioning
Ann. N.Y. Acad. Sci.,
May 1, 2007;
1104(1):
147 - 171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Ward, I. Tkac, Y. Jing, B. Felt, J. Beard, J. Connor, T. Schallert, M. K. Georgieff, and R. Rao
Gestational and Lactational Iron Deficiency Alters the Developing Striatal Metabolome and Associated Behaviors in Young Rats
J. Nutr.,
April 1, 2007;
137(4):
1043 - 1049.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-C. Dreher, P. Kohn, and K. F. Berman
Neural Coding of Distinct Statistical Properties of Reward Information in Humans
Cereb Cortex,
April 1, 2006;
16(4):
561 - 573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Diaz-Mataix, M. C. Scorza, A. Bortolozzi, M. Toth, P. Celada, and F. Artigas
Involvement of 5-HT1A Receptors in Prefrontal Cortex in the Modulation of Dopaminergic Activity: Role in Atypical Antipsychotic Action
J. Neurosci.,
November 23, 2005;
25(47):
10831 - 10843.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Benavides-Piccione, J. I. Arellano, and J. DeFelipe
Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex
Cereb Cortex,
October 1, 2005;
15(10):
1584 - 1591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Sun, Y. Zhao, and M. E. Wolf
Dopamine Receptor Stimulation Modulates AMPA Receptor Synaptic Insertion in Prefrontal Cortex Neurons
J. Neurosci.,
August 10, 2005;
25(32):
7342 - 7351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Wang, Y. Shaham, D. Zitzman, S. Azari, R. A. Wise, and Z.-B. You
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
J. Neurosci.,
June 1, 2005;
25(22):
5389 - 5396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Morishima, T. Miyakawa, T. Furuyashiki, Y. Tanaka, H. Mizuma, and S. Nakanishi
Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice
PNAS,
March 15, 2005;
102(11):
4170 - 4175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Paspalas and P. S. Goldman-Rakic
Presynaptic D1 Dopamine Receptors in Primate Prefrontal Cortex: Target-Specific Expression in the Glutamatergic Synapse
J. Neurosci.,
February 2, 2005;
25(5):
1260 - 1267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Bossert, S. Y. Liu, L. Lu, and Y. Shaham
A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking
J. Neurosci.,
November 24, 2004;
24(47):
10726 - 10730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. T. Papadeas, B. L. Blake, D. J. Knapp, and G. R. Breese
Sustained Extracellular Signal-Regulated Kinase 1/2 Phosphorylation in Neonate 6-Hydroxydopamine-Lesioned Rats after Repeated D1-Dopamine Receptor Agonist Administration: Implications for NMDA Receptor Involvement
J. Neurosci.,
June 30, 2004;
24(26):
5863 - 5876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
