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Electrophysiological Interactions between Striatal Glutamatergic and Dopaminergic Systems
ANTHONY R. WESTa,
STAN B. FLORESCOb,
ALI CHARARAc,
J. AMIEL ROSENKRANZd AND
ANTHONY A. GRACEc
aDepartment of Neuroscience, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois 60064, USA
bDepartment of Psychology, University of British Columbia, Vancouver British Columbia, V6T 1Z4, Canada
cDepartments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
dDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77005, USA
Address for correspondence: Anthony R. West, Ph.D., Department of Neuroscience, Finch University of Health Sciences/The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064. Voice: 847-578-8658; fax: 847-578-8515.
westa{at}finchcms.edu
Ann. N.Y. Acad. Sci. 1003: 53-74 (2003).
Glutamatergic and dopaminergic systems play a primary role in frontal-subcortical circuits involved in motor and cognitive functions. Considerable evidence has emerged indicating that the complex interaction between these neurotransmitter systems within the dorsal striatum and nucleus accumbens is critically involved in the gating of information flow in these highly integrative brain regions. As a result, disruptions of the interaction between glutamate and dopamine has been proposed as a pathological basis for a number of disorders, including the pathophysiology of schizophrenia. In this chapter, we discuss recent studies that have significantly advanced our understanding of the reciprocal interactions between glutamatergic and dopaminergic systems within the striatal complex in the normal brain and in pathological states.
Key Words: glutamate • dopamine • striatum • nucleus accumbens • medium spiny neuron
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