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Single Nucleotide Polymorphism Study of IDDM 17 in a Bedouin Arab Family
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Address for correspondence: Pamela Fain, M.D., Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262. Voice: 303-315-7108; fax: 303-315-4892. pamela.fain{at}uchsc.edu Ann. N.Y. Acad. Sci. 1005: 348-351 (2003).
Type 1 diabetes is an autoimmune disease caused by a combination of genetic and environmental factors. On the basis of a genomic search for linkage in a Bedouin Arab family with 19 members with type 1 diabetes, we previously mapped the IDDM 17 locus to the chromosome 10q25.1 region. The result from a recent genome scan showed suggestive evidence of linkage of IDDM 17 in a subset of Caucasian families in which all affected individuals have DR3, indicating that the IDDM 17 locus might have a measurable effect in Caucasian populations from the United Kingdom and the United States. High-resolution SNP typing provides strong evidence of linkage disequilibrium to the IDDM 17 locus.
Key Words: type 1 diabetes • insulin-dependent diabetes mellitus (IDDM) • IDDM 17 • single nucleotide polymorphism (SNP) This article has been cited by other articles:
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