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Insulin Resistance in Latent Autoimmune Diabetes of Adulthood
aLawson Health Research Institute, bRobarts Research Institute, cLondon Health Sciences Centre, and dSt. Joseph's Health Care, University of Western Ontario, London, Ontario, Canada
Address for correspondence: Dr. Margaret T. Behme, Siebens-Drake Research Institute, 1400 Western Road, London, Ontario, Canada N6G 2V4. Voice: 519-663-3521; fax: 519-663-3847. mbehme{at}uwo.ca Ann. N.Y. Acad. Sci. 1005: 374-377 (2003).
Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age.
Key Words: latent autoimmune diabetes of adulthood (LADA) • homeostasis model assessment (HOMA) • insulin resistance This article has been cited by other articles:
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