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Redox Metals in Alzheimer's Disease
George M. Leader Family Laboratory for Alzheimer's Disease Research, Department of Neural and Behavioral Sciences, Pennsylvania State University School of Medicine, Hershey, Pennsylvania, USA
Address for correspondence: James R. Connor, George M. Leader Family Laboratory for Alzheimer's Disease Research, Department of Neural and Behavioral Sciences, Pennsylvania State University School of Medicine, Hershey, PA 17033. Voice: 717-531-6408; fax: 717-531-5184. jrc3{at}psu.edu Ann. N.Y. Acad. Sci. 1012: 171-178 (2004).
Redox metals in the brain play many important roles in maintenance of cellular function. The maintenance of their homeostasis is of paramount importance to a number of diseases such as Alzheimer's disease and multiple sclerosis. Iron, copper, and zinc are metals of special interest in the pathogenesis of these disorders. This review will focus primarily on iron.
Key Words: Alzheimer's disease (AD) • redox metal • iron • copper • zinc • brain
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