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Kronos Longevity Research Institute, Phoenix, Arizona 85016, USA
Address for correspondence: S. Mitchell Harman, M.D., Ph.D., Kronos Longevity Research Institute, Phoenix, AZ 85016. Voice: 602-778-7499; fax: 602-778-7490. mitch.harman{at}kronosinstitute.org Ann. N.Y. Acad. Sci. 1019: 299-308 (2004).
It is clear that aging results in alterations of endocrine physiology, which in turn appear to contribute to development of the senescent phenotype. How the underlying basic aging process or processes cause the endocrine cell dysfunctions leading to hormone imbalance is far from clear, but oxidative alteration of cell membranes is an attractive candidate mechanism that might be susceptible to some degree of global remediation.
Key Words: hormones • aging • diet • cell • damage • oxidative stress
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