Main |
Browse Volumes |
Forthcoming Volumes |
Annals PrePrints |
Annals Extra |
E-mail Alerts |
Subscriptions & Orders |
New Proposals |
Author Guidelines |
About Annals |
Help |
 |
|
|
|
|
|
Aging, Exercise, and Cardioprotection
SCOTT K. POWERS,
JOHN QUINDRY AND
KARYN HAMILTON
Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
Address for correspondence: Scott K. Powers, Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611. Voice: 352-392-9575, ext. 1343; fax: 352-392-0316. spowers{at}hhp.ufl.edu
Ann. N.Y. Acad. Sci. 1019: 462-470 (2004).
Myocardial ischemia-reperfusion (I-R) injury is a major contributor to the morbidity and mortality associated with coronary artery disease. The incidence of I-R events is greatest in older persons, and studies also indicate that the magnitude of myocardial I-R injury is greater in senescent individuals compared to younger adults. Regular exercise has been confirmed as a pragmatic countermeasure to protect against I-R-induced cardiac injury. Specifically, endurance exercise has been proven to provide cardioprotection against an I-R insult in both young and old animals. Proposed mechanisms to explain the cardioprotective effect of exercise include the induction of myocardial heat shock proteins (HSPs), improved cardiac antioxidant capacity, and/or elevation of other cardioprotective proteins. Of these potential mechanisms, evidence indicates that elevated myocardial levels of heat shock proteins or antioxidants can provide myocardial protection against I-R injury. At present, which of these protective mechanisms is essential for exercise-induced cardioprotection remains unclear. Understanding the molecular basis for exercise-induced cardioprotection is important in developing exercise paradigms to protect the heart during an I-R insult.
Key Words: heart • ischemia-reperfusion • antioxidants • heat shock proteins
This article has been cited by other articles:
|
|
|
|
 
A. N. Kavazis, J. M. McClung, D. A. Hood, and S. K. Powers
Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuli
Am J Physiol Heart Circ Physiol,
February 1, 2008;
294(2):
H928 - H935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Jahangir, S. Sagar, and A. Terzic
Aging and cardioprotection
J Appl Physiol,
December 1, 2007;
103(6):
2120 - 2128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ferdinandy, R. Schulz, and G. F. Baxter
Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning
Pharmacol. Rev.,
December 1, 2007;
59(4):
418 - 458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Quindry, K. L. Hamilton, J. P. French, Y. Lee, Z. Murlasits, N. Tumer, and S. K. Powers
Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosis
J Appl Physiol,
September 1, 2007;
103(3):
1056 - 1062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Viappiani and R. Schulz
Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease
Am J Physiol Heart Circ Physiol,
June 1, 2006;
290(6):
H2167 - H2168.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. French, J. C. Quindry, D. J. Falk, J. L. Staib, Y. Lee, K. K. W. Wang, and S. K. Powers
Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition
Am J Physiol Heart Circ Physiol,
January 1, 2006;
290(1):
H128 - H136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Fluck
Hypoxaemia enhanced peripheral muscle oxidative stress in COPD
Thorax,
October 1, 2005;
60(10):
797 - 798.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Selsby and S. L. Dodd
Heat treatment reduces oxidative stress and protects muscle mass during immobilization
Am J Physiol Regulatory Integrative Comp Physiol,
July 1, 2005;
289(1):
R134 - R139.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. P.M. van Empel, A. T. Bertrand, R. van der Nagel, S. Kostin, P. A. Doevendans, H. J. Crijns, E. de Wit, W. Sluiter, S. L. Ackerman, and L. J. De Windt
Downregulation of Apoptosis-Inducing Factor in Harlequin Mutant Mice Sensitizes the Myocardium to Oxidative Stress-Related Cell Death and Pressure Overload-Induced Decompensation
Circ. Res.,
June 24, 2005;
96(12):
e92 - e101.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Juhaszova, C. Rabuel, D. B. Zorov, E. G. Lakatta, and S. J. Sollott
Protection in the aged heart: preventing the heart-break of old age?
Cardiovasc Res,
May 1, 2005;
66(2):
233 - 244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
