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CXC Chemokines: Angiogenesis, Immunoangiostasis, and Metastases in Lung Cancer
ROBERT M. STRIETERa,b,
JOHN A. BELPERIOa,
MARIE D. BURDICKa,
SHERVEN SHARMAa,
STEVEN M. DUBINETTa AND
MICHAEL P. KEANEa
Departments of aMedicine and bPathology and Laboratory Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90024-1922, USA
Address for correspondence: Robert M. Strieter, M.D., Departments of Medicine, and Pathology and Laboratory Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90024-1922. Voice: 310-794-1999; fax: 310-794-1998. rstrieter{at}mednet.ucla.edu
CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinical strategies to target CXC chemokines in non-small cell lung cancer.
Key Words: CXC chemokines • angiogenesis • tumor growth • tumor metastases
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