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Issue 1030 coverSignal Transduction Pathways, Chromatin Structures, and Gene Expression Mechanisms as Therapeutic Targets Volume 1030 published December 2004
Ann. N.Y. Acad. Sci. 1030: 508–536 (2004). doi: 10.1196/annals.1329.063
Copyright © 2004 by the New York Academy of Sciences
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Comparison of Gene Expression in Intra-Abdominal and Subcutaneous Fat: A Study of Men with Morbid Obesity and Nonobese Men Using Microarray and Proteomics

ABDOMINAL OBESITY STUDY GROUP, FINN EDLER VON EYBENa,b, JENS PETER KROUSTRUPc, JENS FROMHOLT LARSENc AND JULIO CELISd

bCenter of Tobacco Control Research, Odense, Denmark
cDepartment of Endocrinology and Department of Surgery, Aalborg University Hospital, Denmark
dCancer Society, Copenhagen, Denmark

aAddress for correspondence: Finn Edler von Eyben, Center of Tobacco Control Research, Birkevej 17, 5230 Odense M, Denmark. Voice: 45 66145862. e-mail: finnvon{at}mail.tele.dk

Extent of intra-abdominal fat had significant linear relations with six metabolic coronary risk factors: systolic and diastolic blood pressure, fasting blood concentrations of glucose, high density lipoprotein (HDL) cholesterol, triglyceride, and plasminogen activator inhibitor-1. Tumor necrosis factor-{alpha} and adiponectin can be biological mediators from the intra-abdominal fat to the metabolic coronary risk factors. Complementarily, we describe a new study that will analyze the gene expression in intra-abdominal and subcutaneous fat on mRNA and protein level using high throughput methods. The study will elucidate further whether intra-abdominal obesity is the common denominator for the different components of the metabolic syndrome.

Key Words: obesity • coronary risk factors • metabolic syndrome • microarray • 2-dimensional gel electrophoresis • cytokines




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