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 -Tocopherol Metabolites in Humans
aDepartment of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden bLinus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
Address for correspondence: Jan Frank, Department of Food Science, Swedish University of Agricultural Sciences, Box 7051, 750 07 Uppsala, Sweden. Voice: +46-18-672063; fax: +46-18-672995. jan.frank{at}lmv.slu.se
Sesame seed and oil consumption previously increased human plasma
 -tocopherol (-T) concentrations. This was attributed to the sesame lignans sesamin and sesamolin. Here, we studied the inhibition of vitamin E metabolism by a single dose of sesame oil lignans coingested with deuterated  - and -tocopherols in human volunteers. The urinary excretion of -T metabolites was significantly lower in sesame oil treated than in control subjects. Concentrations of tocopherols in blood were not affected by the treatment. In conclusion, a single dose of sesame oil, containing 136 mg sesame lignans (sesamin and sesamolin), reduces the urinary excretion of co-administered -T in humans.
Key Words: carboxyethyl hydroxychromans • CEHC • lignans • sesame • sesamin • sesamolin • tocopherol • vitamin E
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