|
 |
|||||||||||||||||||
|
|||||||||||||||||||
|
|||||||||||||||||||
 |
 |
|
|
Cortisol Stress Response Is Positively Correlated with Central Obesity in Obese Women with Binge Eating Disorder (BED) before and after Cognitive-Behavioral Treatment
New York Obesity Research Center, Departments of Medicine and Psychiatry, St. Luke's/Roosevelt Hospital Center, Columbia University-College of Physicians and Surgeons, New York, New York 10025, USA
Address for correspondence: Marci Gluck, PhD, New York Obesity Research Center, Departments of Medicine and Psychiatry, St. Luke's/Roosevelt Hospital Center, New York, NY 10025. Voice: 212-523-4574; fax: 212-523-4830. Marci513{at}aol.com
Stress is the most commonly reported trigger of binge eating, and high cortisol levels are positively related to both central body fat and food intake after laboratory stress. We therefore examined waist circumference (WHR) and cortisol stress responsivity after a cold pressor stress test (CPT) in 22 obese (BMI > 27) women (11 BED, 11 non-BED). BMI and WHR did not differ between groups. The BED group had higher morning basal cortisol than the non-BED group (P = .03) and greater AUC cortisol after CPT, after controlling for AUC insulin (P = .04). In the BED group, WHR was related to AUC cortisol (P = .002) and peak cortisol stress responsivity (P = .003). Twenty (10 non-BED, 10 BED) were randomized to a 6-week treatment program (CBT + Diet) or Wait-List (WL) control group. There were no BED group or treatment-group differences in WHR, morning basal cortisol, or AUC cortisol after CPT. The relationship between WHR and both AUC cortisol (P = .002) and peak cortisol stress responsivity after CPT (P = .008) remained significant in the BED group. In BED, there is a hyperactive HPA axis related to abdominal obesity that persists even after treatment, suggesting that cortisol might be a primary factor in the disorder.
Key Words: stress responsivity • central fat • waist to hip ratio (WHR) • eating disorder • obesity This article has been cited by other articles:
| |||||||||||||||||||||||||||||||||||||||||
 |
 |
