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Issue 1032 coverBiobehavioral Stress Response: Protective and Damaging Effects Volume 1032 published December 2004
Ann. N.Y. Acad. Sci. 1032: 35–51 (2004). doi: 10.1196/annals.1314.004
Copyright © 2004 by the New York Academy of Sciences
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The Revolutionary Health Science of Psychoendoneuroimmunology: A New Paradigm for Understanding Health and Treating Illness

OAKLEY RAY

Vanderbilt University, Nashville, Tennessee 37212, USA

Address for correspondence: Oakley Ray, 1608 17th Avenue South, Nashville, TN 37212. Voice: 1-615-343-2068. oray{at}cinp.org

This paper reviews the social and behavioral factors acting on the brain that influence health, illness, and death. Using data from several areas of research, a new paradigm is proposed for understanding health and illness. This paradigm, psychoendoneuroimmunology (PENI), provides both the concepts and the mechanisms for studying and explaining mind-body relationships. The brain is the body's first line of defense against illness, and the mind is the functioning of the brain. PENI incorporates ideas, belief systems, hopes, and desires as well as biochemistry, physiology, and anatomy. As we change our thoughts, we are changing our brain and thus our biology and our body. Belief systems set a baseline for the brain upon which other variables will act and have their effects.

Key Words: health • illness • mind • immune system • belief systems




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