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The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nobel Prize in Physiology or Medicine, 1977; Lasker Award, Basic Medical Research, 1975. Address for correspondence: Roger Guillemin, MD, PhD, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037. Voice: 858-455-9322; fax: 858-625-0688. Guillemin{at}salk.edu
This paper is a short review of the traditionally obvious diseases of neuroendocrine origin (diabetes insipidus, Kallman syndrome, etc.), but also of the newly recognized participation of several peptides originally characterized in the hypothalamus and of their receptors, in a series of diseases, both in internal medicine and in psychiatry (rheumatoid arthritis, inflammation, carcinoids, anxiety, depression, etc.). The concept of neuropeptides is now vastly expanded, as these molecules and their several receptors are now known to be widely distributed throughout the brain and the periphery with increasing evidence of paracrine and autocrine modes of action.
Key Words: neuropeptides • receptors • hypothalamus • paracrine secretions
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