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Effect of 4-Aminopyridine on Upbeat and Downbeat Nystagmus Elucidates the Mechanism of Downbeat Nystagmus
Center for Sensorimotor Research, Department of Neurology, Ludwig-Maximilian-University, D-81377 Munich, Germany
Address for correspondence: Stefan Glasauer, Zentrum für Sensomotorik, Klinikum Großhadern, Marchioninistr. 23, D-81377 München, Germany. Voice: +0049-89-7095-4839; fax: +0049-89-7095-4805. sglasauer{at}nefo.med.uni-muenchen.de
The potassium channel blocker 4-aminopyridine (4-AP) restored vertical smooth pursuit and gaze holding in light in one patient with upbeat (UBN) and in one with downbeat nystagmus (DBN). Without a visible target, however, 4-AP had no effect on UBN, but DBN vanished. We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN.
Key Words: patient • cerebellum • potassium channel blocker This article has been cited by other articles:
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