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Smooth Pursuit in Patients with Downbeat Nystagmus
STEFAN GLASAUER,
MUNA HOSHI AND
ULRICH BÜTTNER
Center for Sensorimotor Research, Department of Neurology, Ludwig-Maximilian-University, D-81377 Munich, Germany
Address for correspondence: Stefan Glasauer, Zentrum für Sensomotorik, Klinikum Großhadern, Marchioninistr. 23, D-81377 München, Germany. Voice: +0049-89-7095-4839; fax: +0049-89-7095-4805. sglasauer{at}nefo.med.uni-muenchen.de
Smooth pursuit and gaze holding in light and darkness was investigated in 19 patients with downbeat nystagmus (DBN) and 17 control subjects. Vertical downward smooth pursuit was selectively impaired in patients, and gaze holding with a visible target was only slightly better than in darkness. The selective impairment of downward pursuit and the poor visual suppression of ocular drift in DBN support the involvement of the floccular lobe, which participates in gaze holding and contains gaze-velocity Purkinje cells with a downward on-direction for smooth pursuit.
Key Words: cerebellum • saccades • fixation • integrator • flocculus • Purkinje cell
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