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The Origin of Downbeat Nystagmus: An Asymmetry in the Distribution of On-Directions of Vertical Gaze-Velocity Purkinje Cells
SARAH MARTIa,
DOMINIK STRAUMANNa AND
STEFAN GLASAUERb
a Neurology Department, Zurich University Hospital, Zurich, Switzerland
b Department of Neurology, Ludwig Maximilians University, Munich, Germany
Address for correspondence: S. Marti, M.D., Neurology Department, Zurich University Hospital, Frauenklinikstrasse 26, CH-8091 Zurich, Switzerland. Voice: +41-1-255-3996; fax: +41-1-255-4380. sarah.marti{at}usz.ch
Various hypotheses on the origin of cerebellar downbeat nystagmus (DBN) have been presented; the exact pathomechanism, however, is still not known. Based on previous anatomical and electrophysiological studies, we propose that an asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells leads to spontaneous upward ocular drift in cerebellar disease, and therefore, to DBN. Our hypothesis is supported by a computational model for vertical eye movements.
Key Words: cerebellum • smooth pursuit • flocculus • ocular drift • neural integrator
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