|
 |
|||||||||||||||||||
|
|||||||||||||||||||
|
|||||||||||||||||||
 |
 |
|
|
Neural Integrator Function in Murine CACNA1A Mutants
Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106-5040, USA
Address for correspondence: J.S. Stahl, Dept. of Neurology, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106-5040. Voice: 216-844-3170; fax: 216-844-5066. jss6{at}case.edu
Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.
Key Words: mouse • cerebellum • channelopathy • calcium • flocculus This article has been cited by other articles:
| |||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
 |
