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Agouti-Related Proteins (AGRPs) and Agouti-Signaling Peptide (ASIP) in Fish and Chicken
aDepartment of Neuroscience, Uppsala University, Biomedical Center, 751 24 Uppsala, Sweden bBiomedical Research and Study Center, University of Latvia, LV1067 Riga, Latvia
Address for correspondence: Helgi B. Schiöth, Department of Neuroscience, Uppsala University, Biomedical Center, Box 593, 751 24 Uppsala, Sweden. Fax: +46-18-51-15-40. helgis{at}bmc.uu.se
We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C-terminal part of agouti-related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two from Fugu (Takifugu rubripes), and three from Tetraodon (Tetraodon nigroviridis). We have thus shown for the first time that both AGRP and ASIP genes exist in many species in "lower vertebrates" and were most probably present in early stages of vertebrate evolution.
Key Words: evolution • ASIP • AGRP • ACTH • fish This article has been cited by other articles:
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