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Cardiac Systems Biology
aDepartment of Bioengineering, University of California San Diego, La Jolla, California 92093, USA bThe Burnham Institute, La Jolla, California 92037, USA
Address for correspondence: Prof. Andrew McCulloch, Ph.D., Department of Bioengineering, University of California San Diego, 9500 Gioman Drive, La Jolla, CA 92093-0412, USA. Voice: 858-534-2547; fax: 858-534-5722. amcculloch{at}ucsd.edu
As more detailed molecular information accumulates on the biology of the heart and other complex systems in health and disease, the need for new integrative analyses and tools is growing. Systems biology and bioengineering seek to use high-throughput technologies and integrative computational analysis to construct networks of the interactions between molecular components in the system, to develop systems models of their functionally integrated biological properties, and to incorporate these systems models into structurally integrated multi-scale models for predicting clinical phenotypes. This review gives examples of recent applications using these approaches to elucidate the electromechanical function of the heart in aging and disease.
Key Words: genomic phenotyping • heart • multi-scale modeling • systems bioengineering
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