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The Stages of Type 1A Diabetes
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80010-1763, USA
Address for correspondence: George S. Eisenbarth, M.D., Ph.D., Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 12801 East 17th Avenue, Aurora, CO 80010-1763, USA. Voice: 303-724-6847; fax: 303-724-6839. george.eisenbarth{at}uchsc.edu
We can now predict the development of type 1 diabetes in man because it is a chronic autoimmune disorder with defined stages of disease. We can also readily prevent the disorder in animal models. A major goal is safe prevention in man, and for this we will almost certainly need a better understanding of pathogenesis, coupled with rigorous clinical trials.
Key Words: NOD mouse • prediction • genetic susceptibility • environmental factor • autoantibody • trial • transplantation • review This article has been cited by other articles:
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