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Departments of Psychology and OB/GYN, McGill University, Montreal, Quebec, Canada H3A 1B1
Address for correspondence: Barbara B. Sherwin, Ph.D., James McGill Professor, Departments of Psychology and OB/GYN, McGill University, 1205 Dr. Penfield Ave., Montreal, Quebec, Canada H3A 1B1. Voice: 514-398-6087; fax: 514-398-4896. barbara.sherwin{at}mcgill.ca
Randomized, controlled trials of estrogen treatment found protective effects of estrogen therapy (ET) on verbal memory in healthy, 45-year-old surgically menopausal women given 17-ß estradiol immediately after surgery. However, no effect was found when conjugated equine estrogens were given to older women years after their surgical menopause. These findings suggest that there is a critical time for the initiation of estrogen following the menopause with regard to its protective effect on memory as well as a specificity of the effect on verbal memory. These factors may explain why no protective effect of ET on cognitive aging was found in the Women's Health Initiative Memory Study.
Key Words: surgical menopause • cognition • memory • estrogen therapy This article has been cited by other articles:
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