|
 |
|||||||||||||||||||
|
|||||||||||||||||||
|
|||||||||||||||||||
 |
 |
|
|
The Institute for Biogenesis Research, University of Hawaii Medical School, Honolulu, Hawaii 96822, USA
Address for correspondence: Ryuzo Yanagimachi, Ph.D., Institute for Biogenesis Research, University of Hawaii Medical School, 1960 East-West Road, Honolulu, HI 96822. Voice: 808-956-8746; fax: 808-956-7316. yana{at}hawaii.edu
During normal fertilization, plasma membranes of a spermatozoon and an oocyte mingle to form a mosaic plasma membrane of a zygote. This may contribute to the polyspermy block of the zygote. Sperm tail components (mitochondria, axonema, and accessory fibers) that enter the oocyte are "digested" without playing major roles in embryo development. The proximal centrosome adjacent to the sperm nucleus may become the center of the sperm aster that brings the male and female pronuclei to the center of the zygote, but it may not be essential for embryonic development per se. Whether sperm RNAs contribute to embryonic development is the subject of controversy. The nucleus is the most important sperm component that enters the oocyte. It is known that 7-15% of the spermatozoa of fertile men are chromosomally abnormal. The proportion of the spermatozoa with subchromosomal abnormalities (including damage at the DNA level) is expected to be even higher. The majority of embryos and fetuses with genomic abnormalities are aborted before reaching term. Structurally abnormal spermatozoa are not necessarily genomically abnormal, even though the incidence of genomically abnormal spermatozoa is higher among structurally abnormal than normal spermatozoa. In mammals, certain genes (estimated to be about 100) in the spermatozoon and oocyte must be "imprinted" in a gender-specific manner to warrant normal embryonic development.
Key Words: sperm • oocyte • chromosome • fertilization • genetic • epigenetic This article has been cited by other articles:
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
 |
