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a Unit of Cellular Biochemistry and Biology, the University of Namur, FUNDP, Rue de Bruxelles, 61 B-5000 Namur, Belgium b Straticell S.A, Rue Lecomte, 14 B-5000 Namur, Belgium
Key Words: senescence • oxidative stress • hydrogen peroxide • fibroblasts • transforming growth factor-  1 (TGF-1)
Address for correspondence: Dr. Olivier Toussaint, Unit of Cellular Biochemistry and Biology, the University of Namur, FUNDP, Rue de Bruxelles, 61 B-5000 Namur, Belgium. Voice: 0032-81-724132; fax: 0032-81-724135. e-mail: olivier.toussaint{at}fundp.ac.be
Premature senescence of human fibroblasts is established after exposure to an acute sublethal concentration of H2O2. Overexpression of transforming growth factor-
1 (TGF-1) was shown to be responsible for the appearance of the biomarkers of senescence in these conditions. Other studies have shown that incubation of human fibroblasts with TGF-1 leads to overexpression of H2O2. In this work, we show an increased production of H2O2 by human fibroblasts as premature senescence is established after an initial exposure to H2O2.
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