|
 |
|||||||||||||||||||
|
|||||||||||||||||||
|
|||||||||||||||||||
 |
 |
|
|
a Institute of Human Genetics, University of Aarhus, Aarhus, Denmark b Institute of Public Health, University of Southern Denmark, Odense, Denmark
Key Words: Werner syndrome • WRN • cognition • normal aging
Address for correspondence: Mari Sild, Institute of Human Genetics, The Bartholin Building, Wilhelm Meyers Allé 240, Aarhus University, DK-8000 Aarhus C, Denmark. Voice: +45 8942 1631; fax: +45 8612 3178. e-mail: sild{at}humgen.au.dk
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found certain close-set SNPs in the 5' flanking region and 5' UTR to be significantly associated with the cognitive functioning level in old age.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
 |
