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a Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy b Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Padova, 35121 Padova, Italy
Key Words: skeletal muscle • differentiation • heat-shock protein • endoplasmic reticulum • myositis
Address for correspondence: Dr. Elena Tarricone, Department of Clinical and Experimental Medicine, Division of Rheumatology, via Giustiniani, 2, 35121 Padova, Italy. Voice: 3333701009; fax: 390498212191. e-mail: elena.tarricone{at}unipd.it
Cells respond to conditions that impair homeostasis through ex novo synthesis of stress proteins, which differ in subcellular localization and biological function and whose differential expression depends on the type of the stressing stimulus and on the involvement of the specific stress-response signaling cascade. The biological significance of such an event is the increased resistance against further perturbations of cell homeostasis, and thus, enhanced survival. We will review briefly the available evidence concerning stress response of skeletal muscle cells, including recent results indicating the involvement of endoplasmic reticulum stress response and proteins in skeletal muscle cell differentiation and in progression of muscle diseases.
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