|
 |
|||||||||||||||||||
|
|||||||||||||||||||
|
|||||||||||||||||||
 |
 |
|
|
a National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, Harbin 150001, People's Republic of China b College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
Key Words: Nipah virus • DNA immunization • F protein • G protein
Address for correspondence: Zhigao Bu, Ph.D., National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, 427 Maduan Street, Harbin 150001, P.R. China. Voice: 86-451-85935062; fax: 86-451-82733132. e-mail: zgb{at}hvri.ac.cn
We investigated the antibody response of DNA immunization with two mammalian codon optimized envelope glycoprotein genes, F and G, of Nipah virus in a mouse model. The results indicated that G gene immunization elicited more significant specific serum IgG response and neutralization antibody response than F gene did, suggesting that the G gene DNA immunization is a potential vaccine strategy against Nipah virus.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
 |
