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Issue 1085 coverThe Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology Volume 1085 published November 2006
Ann. N.Y. Acad. Sci. 1085: 29–38 (2006). doi: 10.1196/annals.1383.039
Copyright © 2006 by the New York Academy of Sciences
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Part I. Epidemiology and Initiatives to Prevent Death from Rupture

A Summary of the Contributions of the VA Cooperative Studies on Abdominal Aortic Aneurysms

FRANK A LEDERLEa

a University of Minnesota, Center for Epidemiological and Clinical Research, VA Medical Center, Minneapolis, MN, USA

Key Words: abdominal aortic aneurysm • veterans • multicenter studies • mortality • surgical treatment

Address for correspondence: Frank A. Lederle, M.D., University of Minnesota, Center for Epidemiological and Clinical Research, VA Medical Center, Minneapolis, MN 55417. Voice: 612-467-1979; fax: 612-725-2237.  e-mail: frank.lederle{at}med.va.gov

The Department of Veterans Affairs Cooperative Studies Program has completed two studies on abdominal aortic aneurysm (AAA) and is currently conducting a third. The first, the Aneurysm Detection and Management (ADAM) Study, consisted of both a screening program, which provided information on the prevalence and associations of AAA, and a randomized trial, which found that survival is not improved by repair of small AAA. The second was a prospective observational study to determine the incidence of rupture in patients with large AAA for whom elective repair was not planned due to medical contraindications or patient refusal. AAA in this population had a high risk of rupture, about 10% per year for AAA > 5.5 cm, and 25% within 6 months for AAA larger than 8.0 cm. The third, the Open Versus Endovascular Repair (OVER) Trial, is a multicenter randomized trial comparing long-term survival following two methods of elective AAA repair.




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