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Mechanism, Stratification, and Treatment
a Department of Surgery, Stanford University Medical Center, Stanford, CA, USA b Palo Alto Institute for Research and Education, Palo Alto, CA, USA c Department of Bioengineering, Stanford University, Stanford, CA, USA
Key Words: abdominal aortic aneurysm • exercise • hemodynamics
Address for correspondence: Ronald L. Dalman, M.D., F.A.C.S., F.A.H.A., Division of Vascular Surgery, Stanford University Medical Center, 300 Pasteur Dr. Suite H3642, Stanford, CA 94305-5642. Voice: 650-723-2031; fax: 650-498-6044. e-mail: rld{at}stanford.edu
Abdominal aortic aneurysm (AAA) is a common and frequently lethal disease of older Americans. No medical therapy has been proven effective in retarding progression of small AAAs prior to surgical repair. With the emerging ability of magnetic resonance (MR) flow imaging and MR-based computational analysis to define aortic hemodynamic conditions, and bio-imaging strategies to monitor aortic inflammation real time in vivo, the opportunity now exists to confirm the potential value of medical interventions such as supervised exercise training as first line therapy for small AAA disease.
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