Design and Functional Activity of Phosphopeptides with Potential Immunomodulating Capacity, Based on the Sequence of Grb2-Associated Binder 1

doi:10.1196/annals.1378.086

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Signal Transduction Pathways, Part B: Stress Signaling and Transcriptional Control Volume 1091 published December 2006
Ann. N.Y. Acad. Sci. 1091: 437–444 (2006). doi: 10.1196/annals.1378.086
Copyright © 2006 by the New York Academy of Sciences
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Part IV. Novel Technological and Therapeutical Approaches
Design and Functional Activity of Phosphopeptides with Potential Immunomodulating Capacity, Based on the Sequence of Grb2-Associated Binder 1

AKOS KERTESZ^a, BALAZS TAKACS^a, GYORGYI VARADI^b, GABOR K. TOTH^b AND GABRIELLA SARMAY^a

^{^a} Department of Immunology, Lorand Eotvos University, Budapest 1117, Hungary ^{^b} Department of Medical Chemistry, University of Szeged, Szeged 6720, Hungary

Key Words: Burkitt lymphoma • Gab1 • immunomodulation • phosphopeptides

Address for correspondence: Gabriella Sarmay, Eotvos Lorand University, Pazmany Peter setany 1/c, 1117 Budapest, Hungary. Voice: 36-1-2090-555; ext.: 8662; fax: 36-1-3812-176. e-mail: sarmayg{at}elte.hu

A cell membrane permeable phosphopeptide corresponding to theSHP-2 binding motif of Grb2-associated binder 1 (Gab1) interfereswith the Gab1 adaptor-dependent functions and modulates B cellreceptor-triggered intracellular signaling in B cell tumors.