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a Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina, USA
Key Words: estradiol • estrogen receptor • uterus • ovary
Address for correspondence: Kenneth S. Korach, Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental and Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Voice: 919-541-3512; fax: 919-541-0696. e-mail: Korach{at}niehs.nih.gov
Technological advances and new tools have brought about tremendous advances in elucidating the roles of estradiol and the estrogen receptors (ERs) in biological processes, especially within the female reproductive system. Development and analysis of multiple genetic models have provided insight into the particular functions of each of the ERs. This article reviews the insights into ER biology in female reproduction gained from the development and use of new types of experimental models.
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