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 -Amyloid as Distinct Local Biomarkers for Alzheimer's Disease
a Molecular Imaging and Diagnostics Advanced Technology Program, Biosciences, GE Global Research Center, Niskayuna, New York, USA b Medical Diagnostics R and D, GE Healthcare, Little Chalfont, Bucks, United Kingdom
Key Words:  -amyloid imaging • plaque • imaging • -amyloid oligomers • soluble -amyloid • biomarkers • Alzheimer's
Address for correspondence: Michael C. Montalto, K1-5D63 One Research Circle, Niskayuna, NY 12309. Voice: 518-387-5409; fax: 518-387-7765. montalto{at}crd.ge.com
-amyloid is a key component of Alzheimer's disease (AD) pathology. Researchers in both academic and industry are actively pursuing the development of imaging tracers and techniques to noninvasively measure local levels of -amyloid in the Alzheimer's brain. This presentation summarizes recent data and discusses the opportunities and challenges of imaging plaques containing fibrillar -amyloid for the early diagnosis and therapeutic monitoring of amyloid targeted therapies. Further, the value and feasibility of measuring the recently described soluble oligomeric form of -amyloid as an alternative noninvasive biomarker is also discussed.
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