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Whole Saliva ProteolysisWealth of Information for Diagnostic Exploitation
EVA J HELMERHORSTa
a Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
Key Words: glandular salivary proteins • whole saliva • oral disease • salivary proteolysis
Address for correspondence: Eva J. Helmerhorst, Ph.D., Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 700 Albany Street, W-201, Boston, MA 02118. Voice: 617-414-1119; fax: 617-638-4924. helmer{at}bu.edu
Whole saliva (WS) protein profiles differ significantly from those of glandular salivary secretions. Rapid proteolysis of the prominent members of the salivary protein families by WS resident proteases appears to be a major cause for the observed differences. We propose that the rate and mode of glandular salivary protein degradation in the oral cavity contains information that could be of unique value in the diagnosis of oral disease.
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