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a Department of Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
Key Words: acidic polymerase protein • (PA) • avian influenza • basic polymerase protein 1 • (PB1) • basic polymerase protein 2 • (PB2) • genomic RNAs • vRNA • influenza A • Orthomyxoviridae • virology
Address for correspondence: Dr. Leo L. M. Poon, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China. Voice: 852-2819-9943; fax: 852-2855-1241. llmpoon{at}hkucc.hku.hk
The outbreaks of avian influenza A virus in poultry and humans over the last decade posed a pandemic threat to human. Here, we discuss the basic classification and the structure of influenza A virus. The viral genome contains eight RNA viral segments and the functions of viral proteins encoded by this genome are described. In addition, the RNA transcription and replication of this virus are reviewed.
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