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a Department of Immunology, University of Washington, Seattle, Washington, USA
Key Words: EAE • multiple sclerosis • CD8 T cells • virus
Address for correspondence: Dr. Joan Goverman, Department of Immunology, HSC Box 357650, University of Washington, 1959 NE Pacific Street Seattle, WA 98195-7650. Voice: 206-685-7604; fax: 206-543-1013. goverman{at}u.washington.edu
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that is believed to have an autoimmune origin. CD4+ T cells have been well studied for their involvement in the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). CD8+ T cells, however, have been overlooked until recently, when more attention has focused on their potential role in pathogenic mechanisms in MS. Here we summarize our work in generating a CD8+ T cell–mediated EAE model. We discuss immune tolerance mechanisms that regulate CD8+ T cells specific for myelin basic protein (MBP), and describe initial results regarding triggers of CD8+ T cell–mediated disease. The availability of CD8+ T cell–mediated EAE models will help to elucidate the pathogenic roles of CD8+ T cells in MS, and provide tools for development of novel therapies for MS.
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