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Preliminary Results
a Rheumatology Division, São Paulo University School of Medicine, São Paulo, Brazil b Department of Int Med B, Center for Autoimmune Diseases, affiliated to Tel Aviv University Sackler Faculty of Medicine, Sheba Medical Center, Tel-Hashomer, Israel c Third Department of Int Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary d Department of Medicine ‘D,’ Meir Medical Center, Kfar-Saba affiliated to Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel e Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel Aviv University, Tel Aviv, Israel
Key Words: vitamin D • anti-vitamin D • autoantibodies • systemic lupus erythematosus • antiphospholipid syndrome • pemphigus vulgaris
Address for correspondence: Yehuda Shoenfeld, M.D., F.R.C.P., Head, Department of Medicine B and Center for Autoimmune Diseases, The Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel. Voice: 972-3-5302652; fax: 972-3-5352855. shoenfel{at}post.tau.ac.il
The aim of this study was to detect antibodies to vitamin D in systemic lupus erythematosus (SLE) and other autoimmune diseases. The results may shed light to a novel aspect of vitamin D deficiency in autoimmune diseases. Sera from 171 patients with SLE, 56 with antiphospholipid syndrome (APS), and 18 with pemphigus vulgaris (PV) were studied employing an enzyme-linked immunosorbent assay for anti-vitamin D antibodies along with 94 healthy blood donors. In parallel, vitamin D concentrations in the serum were determined by a DiaSorin commercial kit (LIAISON 25 OH vitamin D). Antibody-positive and antibody-negative individuals were compared with respect to demographic variables, SLE disease activity index (SLEDAI) score, autoantibodies profile, and serum vitamin D levels. Anti-vitamin D antibodies were detected in 7 (4%) of 171 patients with SLE, in 2 (3.5%) of 56 of sera from patients with APS, and in 2 (11%) of 18 sera from patients with PV. Vitamin D levels were similar in both SLE groups with and without anti-vitamin D antibodies. Demographic features, organ involvement, SLEDAI score, and autoantibodies did not differ between the groups. Except for anti-dsDNA antibodies, in which anti-vitamin D antibodies were strongly associated with these antibodies in sera from SLE patients (P = 0.0004). Anti-vitamin D antibodies are observed in a subset of patients with SLE, APS, and PV, and are associated with anti-dsDNA antibodies in SLE. Further studies are required to explore the potential diagnostic and prognostic role of these novel antibodies in SLE.
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