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a Cell Biology Section, NIDCR, NIH, Bethesda, Maryland, USA
Key Words: cell migration • hair follicle growth • angiogenesis • wound healing • stem cells • cell survival • inflammation • gene expression • laminin-5 • proteases • zyxin • endothelial cells • thymosin beta 4 • keratinocytes • MMPs • TIMPs
Address for correspondence: Hynda K. Kleinman, Ph.D., Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892. Voice: 301-496-4069; fax: 301-402-0897. hkleinman{at}dir.nidcr.nih.gov
Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.
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