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a Department of Immunology, Central and Eastern Clinical School, Monash University, Prahan, Victoria 3181, Australia b Prince Henry's Institute of Medical Research, Melbourne, Australia
Key Words: estrogen • telomerase • aging • adrenal
Address for correspondence: Dr. Jun-Ping Liu, Department of Immunology, AMREP, Monash Medical School, Commercial Road, Prahran, Victoria 3181, Australia. Voice: 61-3-99030715; fax: 61-3-99030120. jun-ping.liu{at}med.monash.edu.au
Estrogen regulates tissue development, function, and aging by regulating expression of critical genes. Recent studies suggest that estrogen promotes cell proliferation by stimulating telomerase activity, an enzyme that plays a key role in extending cell life span. In some estrogen-responsive tissues, estrogen appears important in regulating telomerase activity in vivo. Further characterization will provide a greater understanding of the link between estrogen, telomerase, and aging.
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