Differential Effects of Vascular Endothelial Growth Factor on Joint Formation during Limb Development

doi:10.1196/annals.1402.024

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Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling Volume 1116 published December 2007
Ann. N.Y. Acad. Sci. 1116: 134–140 (2007). doi: 10.1196/annals.1402.024
Copyright © 2007 by the New York Academy of Sciences
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Articles by CHIMAL-MONROY, J.

Part I. New Insights into Bone Development
Differential Effects of Vascular Endothelial Growth Factor on Joint Formation during Limb Development

GLORIA EMELÍ CORTINA-RAMÍREZ^a AND JESÚS CHIMAL-MONROY^a

^{^a} Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, México DF, México

Key Words: joint formation • cartilage • chondrocyte • digit development • VEGF • TGF-β

Address for correspondence: Jesús Chimal-Monroy, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70228, Ciudad Universitaria, México DF 04510, México. Voice: 5255-5622-3819; fax: 5255-5622-3897. jchimal{at}servidor.unam.mx

During skeletal development the proliferating chondrocytes choosebetween two fates: to differentiate into prejoint cells or undergohypertrophy. Vascular endothelial growth factor (VEGF) participatesin endochondral ossification, but it is unknown whether it hasa role in joint development. We evaluated the VEGF effects onjoints, implanting VEGF-beads in the presumptive limb jointsof chick embryos. The wrist and elbow showed partial and completefusions. Using the model of ectopic digits induced by transforminggrowth factor-β (TGF-β), VEGF inhibited joint formationwhen it was applied after TGF-β. These data suggest differentialeffects of VEGF on different joints during development.