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a National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
Key Words: nuclear receptors • osteoporosis • Nuclear Receptor Signaling Atlas • NURSA
Address for correspondence: Ronald Margolis, Ph.D., Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 6707 Democracy Blvd., Room 693, Bethesda, MD 20892-5460. Voice: 301-594-8819; fax: 301-435-6047. rm76f{at}nih.gov
Nuclear receptors (NRs) represent a class of ligand-dependent and -independent transcription factors with importance to the regulation of development, reproduction, and metabolism. The emergence of new understanding of the structure, function, and role in disease of NRs provides new insights into the interaction between genetics and the environment, with NRs representing new targets for the development of therapeutic agents. NRs play key roles in bone health and contribute to our understanding of diseases and disorders that result in osteopenia and osteoporosis. The Nuclear Receptor Signaling Atlas (http://www.nursa.org) is an online repository of information about NRs and provides a community-wide resource designed to help catalyze new advances in biology and medicine.
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