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Part III. Regulation of Skeletal Remodeling |
Bone Loss in Thyroid DiseaseRole of Low TSH and High Thyroid Hormone
ETSUKO ABEa,
LI SUNa,
JEFFREY MECHANICKa,
JAMEEL IQBALa,
KOSJ YAMOAHa,
RAMKUMARIE BALIRAMa,
ARIO ARABIa,
BALJIT S. MOONGAa,
TERRY F. DAVIESa AND
MONE ZAIDIa
a Mount Sinai Bone Program and The Thyroid Research Unit at the James Peter's Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York New York, USA
Key Words: thyroid receptor • osteoporosis • bone remodeling
Address for correspondence: Etsuko Abe, Ph.D., P.O. Box 1055, Mount Sinai School of Medicine, New York, NY 10029. Voice: 212-241-8735; fax: 212-241-4218. Etsuko.abe{at}mssm.edu
More than 10% of postmenopausal women in the United States receive thyroid hormone replacement therapy and up to 20% of these women are over-replaced inducing subclinical hyperthyroidism. Because hyperthyroidism and post menopausal osteoporosis overlap in women of advancing age, it is urgent to understand the effect of thyroid hormone excess on bone. We can now provide results that not thyroid hormones but also TSH itself has an equally important role to play in bone remodeling.
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