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Ghrelin versus Leptin
a Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA b Department of Pharmacology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany c Division of Hypothalamic Research and Division of Endocrinology & Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Key Words: ghrelin • leptin • central nervous system • energy balance equation • energy partitioning • melanocortin
Address for correspondence: Jeffrey M. Zigman, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, MC 9077, Dallas, TX 75390-9077. Voice: +1-214-648-6422; fax: +1-214-648-5612. jeffrey.zigman{at}utsouthwestern.edu
In this brief review, we introduce some major themes in the regulation of energy, lipid, and glucose metabolism by the central nervous system (CNS). Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS.
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