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 -(Carboxymethyl)lysine during the Early Development of Hypertension
a Department of Pharmacology and Toxicology, University Maastricht, Maastricht, the Netherlands b Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany c Department of Internal Medicine, Division of General Internal Medicine, University Hospital Maastricht, Maastricht, the Netherlands
Key Words: N  -(carboxymethyl)lysine • hypertension • spontaneously hypertensive rat • renal function • oxidative stress
Address for correspondence: Dr. Marcus Baumann, Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Voice: +0049-89-4140-6704; fax: +0049-89-4140-4878. Marcus.baumann{at}lrz.tum.de
Advanced glycation end products (AGEs) are associated with hypertension. Whether N
-(carboxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to WKY. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 ± 0.3 vs. 1.3 ± 0.2 µmol/L) and kidney (1.0 ± 0.1 vs. 0.5 ± 0.1 µmol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.
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