 | TOWARDS PROLONGATION OF THE HEALTHY LIFE SPAN: Practical Approaches to Intervention
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 854:102-117 (1998)
© 1998 New York Academy of Sciences
Oxidative Stress and Aging: Role of Exercise and Its Influences on Antioxidant Systems
LI LI JIa,
CHRIS LEEUWENBURGH,
STEVE LEICHTWEIS,
MITCH GORE,
RUSSEL FIEBIG,
JOHN HOLLANDER AND
JEFFERY BEJMA
Department of Kinesiology and Nutritional Sciences, and Institute on Aging, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, Wisconsin 53706, USA
aTel: 608/262-7250; fax: 608/262-1656; e-mail: ji{at}soemadison.wisc.edu
Strenuous exercise is characterized by an increased oxygen consumption and disturbance of intracellular prooxidant-antioxidant homeostasis. At least three biochemical pathways, that is, mitochondrial electron transport chain, xanthine oxidase, and polymorphoneutrophil have been identified as potential sources of intracellular free radical generation during exercise. These deleterious reactive oxygen species pose a serious threat to the cellular antioxidant defense system, such as diminished reserve of antioxidant vitamins and glutathione, and have been shown to cause oxidative damage in exercising and/or exercised muscle and other tissues. However, enzymatic and nonenzymatic antioxidants have demonstrated great versatility and adaptability in response to acute and chronic exercise. The delicate balance between prooxidants and antioxidants during exercise may be altered with aging. Study of the complicated interaction between aging and exercise under the influence of reactive oxygen species would provide more definitive information as to how much aged individuals should be involved in physical activity and whether supplementation of nutritional antioxidants would be desirable.
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