 | OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 855:199-204 (1998)
© 1998 New York Academy of Sciences
Role of Cyclic GMP in Olfactory Transduction and Adaptationa
FRANK ZUFALLb,c AND
TRESE LEINDERS-ZUFALLb
Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
aSupported in part by grants from the National Institute of Deafness and Other Communications Disorders to F.Z. (DC-02227 and NS 37748).
bNew address: Dept. of Anatomy and Neurobiology, University of Maryland, 685 West Baltimore St., Baltimore, MD 21201.
cCorresponding author. Tel: (410) 706-3312; fax: (410) 706-2512; email: fzufa001{at}umaryland.edu
The detection of odor molecules by vertebrate olfactory receptor neurons (ORNs) involves signal transduction mechanisms that are thought to occur primarily through a cyclic adenosine monophosphate (cAMP)-mediated second messenger pathway. There has been intense debate whether cAMP is the sole second messenger responsible for all excitation and adaptation. The recent identification of a distinct form of odor adaptation that depends on the carbon monoxide/cyclic guanosine monophosphate (cGMP) second messenger system demonstrates that cAMP alone cannot account for all phases of adaptation and that multiple second messenger pathways exist in ORNs to perform distinct but closely related olfactory functions.
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