OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 855:486-487 (1998)
© 1998 New York Academy of Sciences
Ionic Mechanism of GABAA Biphasic Synaptic Potentials in Gustatory Nucleus of the Solitary Tracta
Gintautas Grabauskasb AND
Robert M. Bradleyb,c,d
bDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, USA
cDepartment of Physiology, Medical School, University of Michigan, Ann Arbor, Michigan 48109-0622, USA
aSupported by NIDCD, NIH Grant DC 00288 to RMB.
dCorrespondence: Robert M. Bradley, Department of Biologic and Materials Sciences, Room 6228, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078. Tel: (734) 763-1080; fax: (734) 764-7406; email: rmbrad{at}umich.edu
Gamma-aminobutyric acid (GABA) is the principal neurotransmitter of synaptic inhibition in the gustatory nucleus of the solitary tract (rNST). High-frequency activation of GABA neurons in the rNST results in biphasic inhibitory postsynaptic potentials (IPSPs) that are initially hyperpolarizing but then became depolarizing. Our results indicate that high-frequency stimulation evokes redistribution of Cl - and K + ions that shifts IPSP reversal potential in a more positive direction, which produces a biphasic or depolarizing IPSP.
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[Abstract]
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