 | INTESTINAL PLASTICITY IN HEALTH AND DISEASE
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 859:18-36 (1998)
© 1998 New York Academy of Sciences
Molecular Basis of Intestinal Adaptation: The Role of the Insulin-like Growth Factor System
P. KAY LUNDa
Departments of Physiology and Pediatrics and Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27514 USA
aAddress for correspondence: Dr. P. Kay Lund, Department of Physiology, University of North Carolina, Chapel Hill, NC 27514. Telephone: 919-966-1490; Fax: 919-966-6927; e-mail: empk{at}med.unc.edu
Ongoing and future approaches to the cellular and molecular actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) in intestinal adaptation are reviewed. This is highly relevant to understanding the benefits and risks associated with increasing use of GH and IGF-I in patients with short bowel syndrome or other bowel diseases. As other growth factors share some of the properties of IGF-I including local expression in bowel, activation of signaling pathways common to other growth factors or cytokines, and modulation of action by growth factor-binding proteins or secreted receptor isoforms. The general issues and approaches outlined for IGF-I should, therefore, serve as a model for studies aimed at understanding the cellular and molecular mechanisms of action of other growth factors that are implicated in intestinal adaptation.
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