NEURONAL MECHANISMS FOR GENERATING LOCOMOTOR ACTIVITY
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 860:412-424 (1998)
© 1998 New York Academy of Sciences
Engines, Accelerators, and Brakes on Functional Spinal Cord Repaira
JOHN D. STEEVESb AND
WOLFRAM TETZLAFF
CORD (Collaboration On Repair Discoveries), Departments of Zoology, Surgery and Anatomy, University of British Columbia, 6270 University Boulevard, Vancouver, B.C., Canada, V6T IZ4
aThis work was supported by grants from the Medical Research Council (Canada), The Natural Sciences and Engineering Research Council (Canada), The Neuroscience Network (Canada), The Rick Hansen Institute (Canada), and The Spinal Cord Research Foundation (USA).
bE-mail: steeves{at}cord.ubc.ca or tetzlaff{at}cord.ubc.ca
It is proposed that four essential goals should be met for functional repair after traumatic injury of the adult spinal cord. These include protecting neural tissue after injury and limiting secondary cell damage; replacing lost tissue with transplanted cell "bridges"; blocking the expression of intrinsic factors within the adult CNS that inhibit neural repair; and providing appropriate sensorimotor activity to enhance plasticity within surviving circuits, as well as consolidate any anatomical repair/regeneration. Included is a brief discussion on the approaches and limitations in the evaluation of functional spinal cord repair.
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