 | NEURONAL MECHANISMS FOR GENERATING LOCOMOTOR ACTIVITY
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 860:70-82 (1998)
© 1998 New York Academy of Sciences
How Do We Approach the Locomotor Network in the Mammalian Spinal Cord?a
H. HULTBORNb,
B. A. CONWAYc,
J.-P. GOSSARDd,
R. BROWNSTONEe,
B. FEDIRCHUKf,
E. D. SCHOMBURGg,
M. ENRÍQUEZ-DENTONh AND
M.-C. PERREAULT
Department of Medical Physiology, Faculty of Health Sciences, University of Copenhagen, Denmark
aOur research in Copenhagen has been supported mainly by grants from the Danish Medical Research Council, the Lundbeck Foundation, the NOVO Nordisk Foundation, and the Human Frontiers Science Program Organization.
bAddress correspondence to Hans Hultborn, Department of Medical Physiology, The Panum Institute, Faculty of Health Sciences, University or Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. E-mail: h.hultborn{at}mfi.ku.dk Present addresses:
cBioengineering Unit, University of Strathclyde, Glasgow, G40 NW, Scotland.
dDepartment of Physiology, University of Montreal, Montreal, PQ, H3T 1J4, Canada.
eDepartment of Physiology, University of Manitoba, Winnipeg, MB, R3E OW3, Canada.
fDepartment of Physiology, University of Manitoba, Winnipeg, MB, R3E 3J7, Canada.
gInstitute of Physiology, University of Göttingen, 37073 Göttingen, Germany.
hInstitute of Biomedical & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
For a large number of vertebrate species it is now indisputable that spinal networks have the capability of generating the basic locomotor rhythm. However, because of technical difficulties, the rate of progress in defining the intrinsic properties of mammalian locomotor rhythm generators has been slow in comparison to that made in the study of such networks in lower vertebrates. Investigations on afferent and descending control of locomotor activity in mammals have demonstrated that many of these pathways interact with the rhythm generator. In this review we discuss how these interactions (resetting) can be used for outlining relevant spinal circuits as a basis for a future identification of individual neurons of the spinal locomotor networks. In this overview we have given particular emphasis to selected afferent systems to illustrate the possibilities and problems with this approach.
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