 | ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICS
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 861:190-203 (1998)
© 1998 New York Academy of Sciences
Regulation of Membrane Excitability in the Central Nervous System by Serotonin Receptor Subtypesa
R. ANDRADEb
Department of Psychiatry and Behavioral Neurosciences and Cellular and Clinical Neurobiology Training Program, Wayne State University School of Medicine, 540 E. Canfield, Detroit, Michigan 48210, USA
aWork in the author's laboratory is supported by NIH Grants MH 43985 and MH49355.
bTel: 313.577.6006; Fax: 313.993.4269; randrade{at}med.wayne.edu
Serotonin exerts multiple electrophysiological effects on neurons of the central nervous system. It is now known that this diversity reflects at least in part the existence of multiple serotonin receptor subtypes. An example of this occurs in the CA1 region of the hippocampus where as many as ten different serotonin receptor subtypes appear to be expressed. Recent electrophysiological studies have been able to assign specific functional roles to at least 5 of these receptors. These receptors are differentially expressed in the two different cell types present in this region, pyramidal cells and GABAergic interneurons, and mediate different effects on membrane excitability. This distribution is consistent with the different functional roles played by these cells in hippocampus. Thus the differential expression of serotonin receptor subtypes in the CA1 region allows serotonin to modify the function of hippocampal neuronal networks in a manner that is both selective and precise.
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