 | GALANIN: BASIC RESEARCH DISCOVERIES AND THERAPEUTIC IMPLICATIONS
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 863:264-273 (1998)
© 1998 New York Academy of Sciences
Electrophysiologic Effects of Galanin on Neurons of the Central Nervous Systema
VINCENT A. PIERIBONEb-d,
ZHI-QING DAVID XUc,
XU ZHANGc AND
TOMAS HÖKFELTc
bThe John B. Pierce Laboratory, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
cThe Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden S-171 77
aThis study was supported by the Swedish MRC (04X-2887), Marianne och Marcus Wallenbergs Stiftelse (VAP, ZQX, XZ, TH), Astra Arcus AB, a Fogarty International Center grant (F20 TWO 1586-01; VAP), and a National Science Foundation grant (INT-8908720; VAP).
dAuthor for correspondence: The John B. Pierce Laboratory; Cellular and Molecular Physiology; Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519. Phone, 203/562-9901, ext. 214; fax, 203/562-9901, ext 285.
The neuropeptidc galanin is found in a large number of neurons and nerve terminals throughout the nervous system. In nerve terminals, galanin is contained in large dense-core vesicles and is released upon electrical stimulation. A variety of electrophysiologic studies have examined the effects of galanin application onto neurons of the central nervous system. Overall, galanin appears to have inhibitory effects in the central nervous system, causing in most cases a potassium-mediated hyperpolarization accompanied by a decrease in input resistance. Other actions include a reduction in presynaptic excitatory inputs and an interaction with other applied neurotransmitters. These effects are robust and long lasting in most cases. Differences in the responses mediated by the various receptor subtypes have not been explored electrophysiologically. More complete analysis awaits the availability of more potent and specific receptor anatagonists.
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